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KMID : 1149220020100010073
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Korean Journal of Oriental Medical Prescription
2002 Volume.10 No. 1 p.73 ~ p.80
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Purgative Effect of Jechun-Jun(Jichuan-Jian) and Add or Omit Herbs in Rat
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Lee Seung-Hee
Lee Sang-Jun
Park Soo-Yeon
Kim Hong-Yeoul
Park Seong-Kyu
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Abstract
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We have examined the purgative effect of three Jechun-jun formulas in sprague dawley(SD) rat. Three jechun-jun formulas were Jechun-jun(Sample I ) and augmented Jechun-jun(Sample II) and augmented Jechun-jun add rhubarb(sample III ). We examined the amount and the humidity of feces in rat. The experimental animals were devided into four groups. as control group and three Jechun-jun (sample I, II, III). We administerd the water extract of sample I, II, III to rat per oral for 8days long. After every 24hours measured the amount of wet feces from rats in metabolic cage. Humidity rate of feces from rat was at first measure wet feces for 24hours (W) and measure dried feces (W1) and then we consider W-W1 as humidity. High humidity rate means constipation changes into moistening stool. The amount of wet feces and humidity rate of feces in rats were increased in sample I, II, III. Sample I has highest humidity rate of feces. so showed strong moistening effect. Sample II has mild effect in treating constipation. sample III has most amount of wet feces. in conclusion Jechun-jun has an effect of moistening stool. and augmented Jechun-jun add rhubarb has strong purgative effect.
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KEYWORD
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constipation, purgative effect, Jechun-jun, rhubarb, amount of wet feces, humidity rate of feces
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